Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5868789 | 0.86 | GSK3B (0.40) | GPR139GSK3BGRM5ALDH1A1VNN1 | |
| SCHEMBL7459390 | 0.83 | GSK3B (0.46) | GPR139GSK3BGRM5RAB9AVNN1 | |
| SCHEMBL7464541 | 0.81 | BCHE (0.36) | GSK3BRAB9AALDH1A1KMT2A | |
| SCHEMBL7467152 | 0.80 | ERCC5 (0.50) | GSK3BRAB9AALDH1A1VNN1KMT2A | |
| SCHEMBL7065166 | 0.78 | VCP (0.45) | GPR139GSK3BGRM5RAB9AHDAC3 | |
| SCHEMBL7459196 | 0.78 | MAPK14 (0.48) | GSK3BGRM5RAB9AALDH1A1VNN1 | |
| SCHEMBL6609458 | 0.77 | GSK3B (0.43) | GPR139GSK3BGRM5RAB9AALDH1A1 | |
| SCHEMBL7465211 | 0.76 | GSK3B (0.40) | GSK3BGRM5RAB9AALDH1A1VNN1 | |
| SCHEMBL7700583 | 0.76 | GSK3B (0.43) | GPR139GSK3BGRM5RAB9AALDH1A1 | |
| SCHEMBL6612119 | 0.75 | GSK3B (0.40) | GPR139GSK3BGRM5RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224175-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029012-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |