Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468043 | 0.89 | MAPT (0.48) | MAPTPOLBTSHRTHRBTP53 | |
| SCHEMBL7468729 | 0.89 | MAPT (0.46) | MAPTPOLBTSHRTHRBTP53 | |
| SCHEMBL7457276 | 0.88 | MAPT (0.47) | MAPTPOLBTSHRTHRBTP53 | |
| SCHEMBL7460793 | 0.88 | MAPT (0.51) | MAPTPOLBTSHRTHRBTP53 | |
| SCHEMBL7463809 | 0.86 | TP53 (0.51) | MAPTPOLBTHRBTP53SMN1; SMN2 | |
| SCHEMBL7465813 | 0.84 | ALDH1A1 (0.43) | MAPTPOLBTSHRTHRBTP53 | |
| SCHEMBL7467509 | 0.82 | MAPT (0.43) | MAPTPOLBTSHRTHRBTP53 | |
| SCHEMBL7472654 | 0.81 | AKR1B1 (0.45) | — | |
| Iodide SCHEMBL7466550 | 0.80 | MAPT (0.38) | MAPTPOLBTSHRTHRBTP53 | |
| SCHEMBL7472637 | 0.79 | MEN1 (0.40) | MAPTPOLBTSHRSMN1; SMN2NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |