Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468729 | 0.96 | MAPT (0.46) | MAPTTHRBTSHRPOLBNLRP3 | |
| SCHEMBL7468043 | 0.96 | MAPT (0.48) | MAPTTHRBTSHRPOLBNLRP3 | |
| SCHEMBL7460793 | 0.92 | MAPT (0.51) | MAPTTHRBTSHRPOLBALDH1A1 | |
| SCHEMBL7465813 | 0.92 | ALDH1A1 (0.43) | MAPTTHRBTSHRPOLBNLRP3 | |
| SCHEMBL7463809 | 0.90 | TP53 (0.51) | MAPTTHRBPOLBALDH1A1HPGD | |
| SCHEMBL7467162 | 0.88 | MAPT (0.42) | MAPTTHRBTSHRPOLBNLRP3 | |
| SCHEMBL7563746 | 0.88 | MAPT (0.49) | MAPTTHRBPOLBKDM4EALDH1A1 | |
| SCHEMBL7467509 | 0.87 | MAPT (0.43) | MAPTTHRBTSHRPOLBNLRP3 | |
| SCHEMBL7468103 | 0.84 | GAA (0.44) | MAPTTHRBALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL7472637 | 0.84 | MEN1 (0.40) | MAPTTSHRPOLBNLRP3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |