Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060885 | 0.86 | CCNB2 (0.62) | RETBRD4CDK9CCNB2CDK1 | |
| SCHEMBL7469256 | 0.86 | CDK1 (0.61) | RETBRD4CDK9CCNB2CDK1 | |
| SCHEMBL7467183 | 0.80 | FLT3 (0.60) | RETBRD4CDK9CCNB2CDK1 | |
| SCHEMBL13185630 | 0.79 | IKBKB (0.60) | MAPKAPK2GSK3BPLK1 | |
| SCHEMBL7460307 | 0.78 | SYK (0.55) | — | |
| SCHEMBL7462357 | 0.78 | CDK1 (0.65) | RETBRD4CDK9CCNB2CDK1 | |
| SCHEMBL12783520 | 0.77 | DYRK1A (0.48) | BRD4CDK9CCNB2CDK1CCNB1 | |
| SCHEMBL3605758 | 0.77 | FADS1 (0.62) | BRD4CDK9PLK1 | |
| SCHEMBL7465536 | 0.74 | ABL1 (0.54) | — | |
| SCHEMBL7475710 | 0.73 | ABL1 (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |