SCHEMBL7467276

SCHEMBL7467276

Cc1cc(F)ccc1Oc1ccnc2c(Cl)cccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.43
KDM4E B2RXH2 2/20 0.41
TRPA1 O75762 1/20 0.41
SLC6A4 P31645 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 2/20 0.40
NPBWR1 P48145 1/20 0.39
MCHR1 Q99705 1/20 0.39
MAPT P10636 1/20 0.39
HTT P42858 1/20 0.39
HSD17B10 Q99714 1/20 0.39
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
PIK3CD O00329 1/20 0.38
PIK3CA P42336 1/20 0.38
PIK3CB P42338 1/20 0.38
PIK3CG P48736 1/20 0.38
MAPK14 Q16539 2/20 0.38
GAA P10253 2/20 0.38
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7044612 0.89 NR4A2 (0.45) NR4A2KDM4ETRPA1SLC6A4SMN1; SMN2
SCHEMBL7462612 0.88 TRPA1 (0.51) NR4A2KDM4ETRPA1SMN1; SMN2ALDH1A1
SCHEMBL18796134 0.87 NR4A2 (0.41) NR4A2KDM4ETRPA1SLC6A4SMN1; SMN2
SCHEMBL7458700 0.86 NR4A2 (0.45) NR4A2KDM4ESLC6A4SMN1; SMN2ALDH1A1
SCHEMBL7464651 0.86 NR4A2 (0.47) NR4A2KDM4ESMN1; SMN2ALDH1A1HTT
SCHEMBL7465640 0.86 NR4A2 (0.42) NR4A2KDM4ETRPA1SMN1; SMN2ALDH1A1
SCHEMBL7531657 0.83 NR4A2 (0.59) NR4A2KDM4ESMN1; SMN2ALDH1A1MAPT
SCHEMBL7461344 0.82 NR4A2 (0.46) NR4A2KDM4ESMN1; SMN2ALDH1A1MAPT
SCHEMBL18118619 0.81 NR4A2 (0.45) NR4A2KDM4ESMN1; SMN2ALDH1A1MAPT
SCHEMBL7461347 0.81 GAA (0.54) KDM4ESMN1; SMN2ALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP claimed
US-5145843-A For plants DOWELANCO (US) 1992-09-08 US claimed
EP-0326330-B1 Quinoline fungicides DOW AGROSCIENCES LLC (US) 2002-07-24 EP disclosed