Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161182 | 1.00 | GPR119 (0.41) | GPR119CASP3CHRNB2CHRNA4USP30 | |
| SCHEMBL3909612 | 0.86 | SCN9A (0.43) | CHRNB2CHRNA4ADRA2CBACE1 | |
| SCHEMBL3909608 | 0.86 | SCN9A (0.43) | CHRNB2CHRNA4ADRA2CBACE1 | |
| SCHEMBL5264109 | 0.85 | CASP3 (0.41) | GPR119CASP3NR1H2ROCK2ATR | |
| SCHEMBL77428 | 0.85 | CASP3 (0.41) | GPR119CASP3NR1H2ROCK2ATR | |
| SCHEMBL28778304 | 0.80 | KMT2A (0.43) | CHRNB2CHRNA4ADRA2C | |
| SCHEMBL13244526 | 0.79 | CNR2 (0.40) | GPR119CASP3ROCK2ATRATRIP | |
| SCHEMBL13244509 | 0.79 | CNR2 (0.40) | GPR119CASP3ROCK2ATRATRIP | |
| SCHEMBL28690247 | 0.77 | CASP3 (0.41) | CASP3BACE1 | |
| SCHEMBL4827642 | 0.75 | CNR2 (0.53) | GPR119CASP3BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178969-A1 | GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000027823-A1 | GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-05-18 | — | — | WO | disclosed |