Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | CTSS | P25774 | 4/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 4/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618230 | 0.95 | CTSK (0.47) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL6635507 | 0.93 | CTSK (0.46) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL6622127 | 0.87 | CTSK (0.47) | CTSKCTSSCTSBAAK1 | |
| SCHEMBL5632090 | 0.83 | L3MBTL1 (0.43) | CTSKCTSSCTSB | |
| SCHEMBL19792930 | 0.80 | BCL2 (0.47) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL7468216 | 0.80 | CTSK (0.53) | CTSKCTSSCTSBCTSLPSMB5 | |
| SCHEMBL7163407 | 0.77 | CTSK (0.47) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL14384115 | 0.76 | L3MBTL1 (0.44) | CTSKCTSSCTSB | |
| SCHEMBL14384114 | 0.76 | L3MBTL1 (0.44) | CTSKCTSSCTSB | |
| SCHEMBL7412248 | 0.75 | CTSK (0.44) | CTSKCTSSCTSBCTSLREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983228-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-0983228-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050342-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |