Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.39 |
| ▸ | HAAO | P46952 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646160 | 0.82 | TDP1 (0.52) | TDP1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3780281 | 0.81 | MAPT (0.66) | TDP1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL11218412 | 0.81 | TDP1 (0.50) | TDP1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4278017 | 0.80 | MAPT (0.64) | TDP1MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL16108037 | 0.80 | HSD17B10 (0.50) | TDP1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL17371291 | 0.79 | TDP1 (0.68) | TDP1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1478662 | 0.78 | ALDH1A1 (0.47) | TDP1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29057071 | 0.78 | HSD17B10 (0.47) | TDP1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1919502 | 0.77 | TDP1 (0.50) | TDP1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2898402 | 0.76 | HAAO (0.42) | TDP1ALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116783179-A | Compounds and methods for targeted degradation of androgen receptor proteins | 阿尔维纳斯运营股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| EP-1023293-A4 | ARYLOXYMETHYL CARBAPENEM ANTIBACTERIALS | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| EP-1086104-A4 | FUSED PHENOXYMETHYL CARBAPENEM ANTIBACTERIALS | MERCK & CO INC (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-1032384-A4 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6284753-B2 | GRAMPOSITVE BACTERIA | MERCK & CO., INC. | 2001-09-04 | — | — | US | disclosed |
| US-6277843-B1 | USEFUL AGAINST GRAMPOSITIVE BACTERIA, I.E., METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS, WITH REDUCED SIDE EFFECTS | MERCK & CO., INC. | 2001-08-21 | — | — | US | disclosed |
| US-20010011086-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. | 2001-08-02 | — | — | US | disclosed |
| EP-1086104-A1 | FUSED PHENOXYMETHYL CARBAPENEM ANTIBACTERIALS | Merck & Co., Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6207823-B1 | ANTIBIOTIC; ANTIBIOTIC RESISTANT INFECTIONS | MERCK & CO., INC. | 2001-03-27 | — | — | US | disclosed |
| EP-1032384-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-1023293-A1 | ARYLOXYMETHYL CARBAPENEM ANTIBACTERIALS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999062907-A1 | FUSED PHENOXYMETHYL CARBAPENEM ANTIBACTERIALS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |
| WO-1999020270-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999014217-A1 | ARYLOXYMETHYL CARBAPENEM ANTIBACTERIALS | MERCK & CO., INC. (US) | 1999-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010011086-A1 | CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | TOP1, NRDC, PAICS | TDP1 4498/4885MAPT 4547/4885ALDH1A1 3690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.