Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.54 |
| ▸ | CA9 | Q16790 | 16/20 | 0.54 |
| ▸ | CA1 | P00915 | 15/20 | 0.54 |
| ▸ | CA4 | P22748 | 5/20 | 0.54 |
| ▸ | CA12 | O43570 | 10/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.53 |
| ▸ | CA5A | P35218 | 3/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.53 |
| ▸ | CA3 | P07451 | 2/20 | 0.53 |
| ▸ | CA6 | P23280 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467884 | 1.00 | CA2 (0.54) | CA2CA9CA1CA4CA12 | |
| SCHEMBL515840 | 0.82 | ENPP2 (0.50) | CA9 | |
| SCHEMBL515841 | 0.82 | ENPP2 (0.50) | CA9 | |
| SCHEMBL6814986 | 0.79 | CA2 (0.51) | CA2CA9CA1CA4CA12 | |
| SCHEMBL6814989 | 0.79 | CA2 (0.51) | CA2CA9CA1CA4CA12 | |
| SCHEMBL7143996 | 0.78 | NOS1 (0.54) | CA2CA9CA1CA4CA12 | |
| SCHEMBL7143991 | 0.78 | NOS1 (0.54) | CA2CA9CA1CA4CA12 | |
| SCHEMBL1338333 | 0.78 | CA2 (0.61) | CA2CA9CA1CA4CA12 | |
| SCHEMBL1338332 | 0.78 | CA2 (0.61) | CA2CA9CA1CA4CA12 | |
| SCHEMBL2772513 | 0.78 | CA2 (0.61) | CA2CA9CA1CA4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |