Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 14/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474934 | 0.86 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL7477860 | 0.85 | CRHR1 (0.53) | KCNH3CRHR1 | |
| SCHEMBL6075389 | 0.78 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL7481401 | 0.77 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL7474850 | 0.77 | CRHR1 (0.46) | TLR8ACHECRHR1 | |
| SCHEMBL7483586 | 0.76 | TLR8 (0.41) | TLR8CRHR1HSP90AB1 | |
| SCHEMBL7482439 | 0.75 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL7478694 | 0.74 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL7481208 | 0.74 | CRHR1 (0.48) | KCNH3CRHR1 | |
| SCHEMBL7480941 | 0.73 | CRHR1 (0.68) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |