Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482439 | 0.89 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL7469231 | 0.86 | TLR8 (0.41) | CRHR1 | |
| SCHEMBL5427390 | 0.83 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL6074443 | 0.82 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL6080630 | 0.78 | CRHR1 (0.80) | CRHR1 | |
| SCHEMBL6075781 | 0.77 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL27501034 | 0.77 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL7474850 | 0.77 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL7481401 | 0.77 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL6166393 | 0.75 | CRHR1 (0.42) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | claimed |