Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | IKBKB | O14920 | 2/20 | 0.59 |
| ▸ | SYK | P43405 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466253 | 0.85 | PIK3CG (0.71) | PIK3CAPIK3CBPIK3CGMAPK1CDK5 | |
| SCHEMBL7470857 | 0.84 | ABL1 (0.63) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL4901565 | 0.82 | MEN1 (0.59) | MEN1KMT2ASYK | |
| SCHEMBL10977837 | 0.82 | PIK3CG (0.78) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL7464407 | 0.81 | SYK (0.59) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL4894535 | 0.81 | SYK (0.62) | PLK1IKBKBSYKCDK2 | |
| SCHEMBL7460307 | 0.81 | SYK (0.55) | SYK | |
| SCHEMBL7476302 | 0.81 | CDK2 (0.58) | AURKBIKBKBSYKCDK2 | |
| SCHEMBL27116184 | 0.81 | SYK (0.65) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL4899553 | 0.80 | ABL1 (0.61) | PIK3CAPIK3CBPIK3CGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |