Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.59 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470857 | 0.87 | ABL1 (0.63) | SYKMEN1NPC1MAPTMAPK1 | |
| SCHEMBL4894535 | 0.85 | SYK (0.62) | SYKCDK2ABL1BCRPRKCA | |
| SCHEMBL7469928 | 0.84 | ABL1 (0.64) | SYKCDK2ABL1BCRPRKCA | |
| Hydrochloric Acid SCHEMBL10769093 | 0.84 | SYK (0.60) | SYKCDK2ABL1BCRPRKCA | |
| SCHEMBL7476302 | 0.81 | CDK2 (0.58) | SYKCDK2ABL1BCRPRKCA | |
| SCHEMBL7460307 | 0.81 | SYK (0.55) | SYKABL1BCRPRKCA | |
| SCHEMBL7469378 | 0.81 | PIK3CA (0.62) | SYKEIF2AK2MEN1NPC1LMNA | |
| SCHEMBL4903032 | 0.79 | MAPK8 (0.74) | SYKCDK2ABL1BCRPRKCA | |
| SCHEMBL7461995 | 0.79 | JAK2 (0.73) | SYK | |
| SCHEMBL7469285 | 0.79 | IKBKB (0.74) | CDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |