Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.71 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.71 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | BCR | P11274 | 1/20 | 0.60 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 4/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 4/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469378 | 0.85 | PIK3CA (0.62) | PIK3CGPIK3CAPIK3CBCDK2CDK5 | |
| SCHEMBL27116598 | 0.84 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBEGFRGSK3B | |
| SCHEMBL7471678 | 0.83 | ABL1 (0.64) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL27116184 | 0.83 | SYK (0.65) | PIK3CGPIK3CAPIK3CBEGFRCDK5 | |
| SCHEMBL27115896 | 0.82 | PIK3CG (0.76) | PIK3CGPIK3CAPIK3CBEGFRABL1 | |
| SCHEMBL7464195 | 0.82 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CBEGFRABL1 | |
| SCHEMBL2284267 | 0.82 | EGFR (0.72) | PIK3CGPIK3CAPIK3CBEGFRCDK2 | |
| SCHEMBL4900091 | 0.81 | MEN1 (0.60) | EGFRABL1BCRPRKCAJAK2 | |
| SCHEMBL4899553 | 0.81 | ABL1 (0.61) | PIK3CGPIK3CAPIK3CBEGFRABL1 | |
| SCHEMBL5999614 | 0.81 | PIK3CG (0.71) | PIK3CGPIK3CAPIK3CBEGFRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |