Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.44 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468246 | 0.90 | OPRK1 (0.49) | NOS2NPC1RAB9AOPRK1METAP1 | |
| SCHEMBL7054705 | 0.90 | OPRK1 (0.49) | NOS2NPC1RAB9AOPRK1METAP1 | |
| SCHEMBL7461745 | 0.84 | CASR (0.55) | NOS2METAP1CASR | |
| SCHEMBL382149 | 0.83 | OPRK1 (0.51) | NOS2NPC1RAB9AOPRK1METAP1 | |
| SCHEMBL383015 | 0.83 | OPRK1 (0.51) | NOS2NPC1RAB9AOPRK1METAP1 | |
| SCHEMBL12193435 | 0.80 | NOS2 (0.47) | NOS2CHRNA7CHRNA10CHRNA9CASR | |
| SCHEMBL7474418 | 0.79 | NPC1 (0.52) | NOS2NPC1RAB9AMETAP1KDM4E | |
| SCHEMBL7466048 | 0.78 | OPRK1 (0.51) | NOS2NPC1RAB9AOPRK1KDM4E | |
| SCHEMBL2408945 | 0.77 | CASR (0.54) | NOS2METAP1CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL382510 | 0.77 | NOS2 (0.51) | NOS2OPRK1METAP1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |