Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473315 | 0.89 | TRPV1 (0.37) | TRPV1KCNE1KCNQ1CYP3A4HTR2A | |
| SCHEMBL7477208 | 0.88 | HSD17B10 (0.41) | TRPV1KCNE1KCNQ1CYP3A4MAPT | |
| SCHEMBL7474303 | 0.85 | TRPV1 (0.46) | TRPV1KCNE1KCNQ1MAPTALDH1A1 | |
| SCHEMBL7472708 | 0.83 | MAPT (0.48) | TRPV1KCNE1KCNQ1MAPTALDH1A1 | |
| SCHEMBL4621983 | 0.82 | KCNE1 (0.45) | TRPV1KCNE1KCNQ1CYP3A4MAPT | |
| SCHEMBL14256398 | 0.82 | KCNE1 (0.45) | TRPV1KCNE1KCNQ1CYP3A4MAPT | |
| SCHEMBL7473827 | 0.79 | KCNA5 (0.38) | TRPV1KCNE1KCNQ1CYP3A4MAPT | |
| SCHEMBL7461292 | 0.79 | KMT2A (0.45) | TRPV1KCNE1KCNQ1ALDH1A1LMNA | |
| SCHEMBL7477203 | 0.79 | TRPV1 (0.42) | TRPV1KCNE1KCNQ1ALDH1A1GAA | |
| SCHEMBL7470001 | 0.78 | KCNE1 (0.42) | TRPV1KCNE1KCNQ1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |