Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473827 | 0.91 | KCNA5 (0.38) | HSD17B10KCNA5TRPV1KCNE1KCNQ1 | |
| SCHEMBL7472708 | 0.88 | MAPT (0.48) | KCNA5TRPV1KCNE1KCNQ1HTT | |
| SCHEMBL7469462 | 0.88 | TRPV1 (0.38) | TRPV1KCNE1KCNQ1HTTALDH1A1 | |
| SCHEMBL7474303 | 0.86 | TRPV1 (0.46) | KCNA5TRPV1KCNE1KCNQ1HTT | |
| SCHEMBL7473315 | 0.86 | TRPV1 (0.37) | TRPV1KCNE1KCNQ1HTTALDH1A1 | |
| SCHEMBL7464041 | 0.85 | SMN1; SMN2 (0.46) | TRPV1KCNE1KCNQ1GAACYP3A4 | |
| SCHEMBL7470001 | 0.84 | KCNE1 (0.42) | TRPV1KCNE1KCNQ1CYP3A4 | |
| SCHEMBL4621983 | 0.83 | KCNE1 (0.45) | HSD17B10TRPV1KCNE1KCNQ1MAPT | |
| SCHEMBL14256398 | 0.83 | KCNE1 (0.45) | HSD17B10TRPV1KCNE1KCNQ1MAPT | |
| SCHEMBL4621868 | 0.81 | KMT2A (0.42) | TRPV1KCNE1KCNQ1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |