Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461292 | 0.93 | KMT2A (0.45) | TRPV1KCNE1KCNQ1HPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL7474459 | 0.91 | TRPV1 (0.41) | TRPV1KCNE1KCNQ1HPGDALDH1A1 | |
| SCHEMBL14256398 | 0.85 | KCNE1 (0.45) | TRPV1KCNE1KCNQ1HSD17B10 | |
| SCHEMBL4621983 | 0.85 | KCNE1 (0.45) | TRPV1KCNE1KCNQ1HSD17B10 | |
| SCHEMBL7474303 | 0.85 | TRPV1 (0.46) | TRPV1KCNE1KCNQ1HPGDALDH1A1 | |
| SCHEMBL7472708 | 0.83 | MAPT (0.48) | TRPV1KCNE1KCNQ1ALDH1A1MEN1 | |
| SCHEMBL7467409 | 0.81 | L3MBTL1 (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6600708 | 0.81 | KDM4E (0.49) | HPGDALDH1A1KDM4ECASP1CASP7 | |
| SCHEMBL7468526 | 0.80 | KCNE1 (0.49) | TRPV1KCNE1KCNQ1 | |
| SCHEMBL4621868 | 0.80 | KMT2A (0.42) | TRPV1KCNE1KCNQ1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905131-B1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | AVENTIS PHARMA GMBH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0905131-A1 | Sulfonamid-substituted chromans, process for their preparation, their use as medicine, and pharmaceutical preparation containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-31 | — | — | EP | disclosed |