Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GLP1R | P43220 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5722680 | 0.83 | TSHR (0.55) | TSHRGLP1RGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7471483 | 0.81 | ALDH1A1 (0.39) | TSHRGLP1RALDH1A1MAPTHPGD | |
| SCHEMBL7464208 | 0.81 | GRIN2D (0.43) | TSHRGLP1RGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7472189 | 0.80 | EPAS1 (0.40) | TSHRGLP1RALDH1A1HPGDDCTPP1 | |
| SCHEMBL7476375 | 0.78 | GRIN2D (0.46) | TSHRGLP1RGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7472466 | 0.77 | GLP1R (0.46) | TSHRGLP1RALDH1A1MAPTHPGD | |
| SCHEMBL7531924 | 0.74 | TSHR (0.60) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7472156 | 0.74 | GRIN2D (0.43) | TSHRGLP1RGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7471616 | 0.74 | KCNH2 (0.38) | TSHRGLP1RALDH1A1 | |
| SCHEMBL7472075 | 0.74 | MEN1 (0.48) | TSHRGLP1RGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |