Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 4/20 | 0.40 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.38 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ARNT | P27540 | 2/20 | 0.37 |
| ▸ | GLP1R | P43220 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 5/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472951 | 0.82 | EPAS1 (0.39) | EPAS1VEGFATSHRALDH1A1CYP3A4 | |
| SCHEMBL7469633 | 0.80 | TSHR (0.39) | EPAS1TSHRALDH1A1CYP3A4HPGD | |
| SCHEMBL5722680 | 0.80 | TSHR (0.55) | TSHRALDH1A1GLP1RDCTPP1 | |
| SCHEMBL7472466 | 0.79 | GLP1R (0.46) | EPAS1TSHRALDH1A1CYP3A4HPGD | |
| SCHEMBL7465352 | 0.79 | EPAS1 (0.40) | EPAS1VEGFATSHRALDH1A1CYP3A4 | |
| SCHEMBL7464208 | 0.77 | GRIN2D (0.43) | TSHRALDH1A1CYP3A4TDP1GLP1R | |
| SCHEMBL7476375 | 0.75 | GRIN2D (0.46) | TSHRALDH1A1GLP1RDCTPP1 | |
| SCHEMBL7471616 | 0.74 | KCNH2 (0.38) | TSHRALDH1A1GLP1R | |
| SCHEMBL7471483 | 0.74 | ALDH1A1 (0.39) | EPAS1TSHRALDH1A1HPGDTDP1 | |
| SCHEMBL11867053 | 0.73 | EPAS1 (0.38) | EPAS1VEGFATSHRALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |