Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 14/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25096120 | 0.79 | TSHR (0.38) | NQO2TSHRALDH1A1GLP1R | |
| SCHEMBL5722680 | 0.77 | TSHR (0.55) | TSHRALDH1A1GLP1R | |
| SCHEMBL7472075 | 0.74 | MEN1 (0.48) | TSHRALDH1A1GLP1R | |
| SCHEMBL7464208 | 0.74 | GRIN2D (0.43) | TSHRALDH1A1GLP1R | |
| SCHEMBL7471483 | 0.74 | ALDH1A1 (0.39) | TSHRALDH1A1GLP1R | |
| SCHEMBL7469633 | 0.74 | TSHR (0.39) | TSHRALDH1A1GLP1R | |
| SCHEMBL7472156 | 0.74 | GRIN2D (0.43) | TSHRALDH1A1GLP1R | |
| SCHEMBL7472189 | 0.74 | EPAS1 (0.40) | TSHRALDH1A1GLP1R | |
| SCHEMBL7476375 | 0.72 | GRIN2D (0.46) | TSHRALDH1A1GLP1R | |
| SCHEMBL7472466 | 0.71 | GLP1R (0.46) | TSHRALDH1A1GLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |