Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
| ▸ | RELA | Q04206 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30659283 | 1.00 | NPC1 (1.00) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 | |
| SCHEMBL27616400 | 0.92 | NPC1 (0.84) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 | |
| SCHEMBL27458472 | 0.88 | NPC1 (0.77) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 | |
| SCHEMBL8760465 | 0.86 | NPC1 (0.76) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 | |
| SCHEMBL8446706 | 0.84 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 | |
| SCHEMBL5215787 | 0.84 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 | |
| SCHEMBL31331181 | 0.84 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 | |
| SCHEMBL18672358 | 0.84 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMMAPT | |
| SCHEMBL30987968 | 0.83 | NPC1 (0.71) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 | |
| SCHEMBL7754907 | 0.83 | NPC1 (0.71) | NPC1RAB9AL3MBTL1NOTUMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950046-B1 | 3,4-DISUBSTITUTED AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE REGULATORS | NAEJA PHARMACEUTICAL INC (CA) | 2002-04-10 | — | — | EP | claimed |
| EP-0709374-B1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | OREAL (FR) | 1997-06-18 | — | — | EP | claimed |
| US-5578735-A | CATALYTIC HYDROGENATION OF INDOLE COMPOUNDS AND REFLUXING | L'OREAL (FR) | 1996-11-26 | — | — | US | claimed |
| EP-0709374-A1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | L'OREAL (FR) | 1996-05-01 | — | — | EP | claimed |
| CN-119325475-A | Bicyclic substituted glutarimide cereblon binders | C4医药公司 | 2025-01-17 | — | — | CN | disclosed |
| WO-2023227125-A1 | NEW FUSED-HETEROCYCLIC COMPOUND AS CDK INHIBITOR AND USE THEREOF | 杭州德睿智药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2022174796-A1 | PYRIMIDINE COMPOUND AS WEE-1 INHIBITOR | 微境生物医药科技(上海)有限公司 | 2022-08-25 | — | — | WO | disclosed |
| CN-109153646-B | Pyridine dicarboxamide derivatives as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2022133588-A1 | RNA VIRUS INHIBITOR COMPOUNDS AND USES THEREOF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2022-06-30 | — | — | WO | disclosed |
| US-20200176077-A1 | STRUCTURAL PREDICTION OF PROTEINS | HUMAN LONGEVITY, INC. | 2020-06-04 | — | — | US | disclosed |
| CN-109153646-A | Pyridine dicarboxamide derivatives as bromine structural domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-108884070-A | PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS | 葛兰素史克知识产权第二有限公司 | 2018-11-23 | — | — | CN | disclosed |
| EP-0709374-A1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | L'OREAL (FR) | 1996-05-01 | — | — | EP | disclosed |
| EP-0702681-A1 | SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS | MERCK & CO. INC. (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5496927-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE, CATHEPSIN G, CHYMOTRYPSIN | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-05 | — | — | US | disclosed |
| WO-1995028931-A1 | SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ-3 ANTAGONISTS | MERCK & CO., INC. (US) | 1995-11-02 | — | — | WO | disclosed |
| US-5434158-A | Asthma | MERCK & CO., INC. (US) | 1995-07-18 | — | — | US | disclosed |
| WO-1994029309-A1 | SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS | MERCK & CO., INC. (US) | 1994-12-22 | — | — | WO | disclosed |
| EP-0195212-B1 | Novel peptidase inhibitors | MERRELL DOW PHARMA (US) | 1993-11-24 | — | — | EP | disclosed |
| EP-0195212-A2 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-09-24 | — | — | EP | disclosed |