Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.76 |
| ▸ | RAB9A | P51151 | 4/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.76 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215787 | 0.87 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL30987968 | 0.87 | NPC1 (0.71) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL7754907 | 0.87 | NPC1 (0.71) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL7469639 | 0.86 | NPC1 (1.00) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL30659283 | 0.86 | NPC1 (1.00) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL5215945 | 0.85 | NPC1 (0.69) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL5212024 | 0.83 | L3MBTL1 (0.66) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL21965354 | 0.82 | RAB9A (0.65) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL29264496 | 0.82 | NPC1 (0.68) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL7749915 | 0.81 | NPC1 (0.62) | NPC1RAB9AL3MBTL1NOTUMTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709374-B1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | OREAL (FR) | 1997-06-18 | — | — | EP | claimed |
| US-5578735-A | CATALYTIC HYDROGENATION OF INDOLE COMPOUNDS AND REFLUXING | L'OREAL (FR) | 1996-11-26 | — | — | US | claimed |
| EP-0709374-A1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | L'OREAL (FR) | 1996-05-01 | — | — | EP | claimed |
| EP-0709374-B1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | OREAL (FR) | 1997-06-18 | — | — | EP | disclosed |
| US-5578735-A | CATALYTIC HYDROGENATION OF INDOLE COMPOUNDS AND REFLUXING | L'OREAL (FR) | 1996-11-26 | — | — | US | disclosed |
| EP-0709374-A1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | L'OREAL (FR) | 1996-05-01 | — | — | EP | disclosed |