Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30987968 | 1.00 | NPC1 (0.71) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL7749915 | 0.88 | NPC1 (0.62) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL8760465 | 0.87 | NPC1 (0.76) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL29264496 | 0.85 | NPC1 (0.68) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL30659283 | 0.83 | NPC1 (1.00) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL7469639 | 0.83 | NPC1 (1.00) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL8446706 | 0.82 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL5215787 | 0.82 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL31331181 | 0.82 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMSMN1; SMN2 | |
| SCHEMBL18672358 | 0.82 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NOTUMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005554-A | Synthesis method of 5, 6-dihydroxyindole and intermediate thereof | 北京颖诺凯胜科技有限公司 | 2024-05-10 | — | — | CN | claimed |
| EP-0604278-B1 | Indoline derivatives and dye compositions for keratinic fibres | OREAL (FR) | 2001-02-21 | — | — | EP | claimed |
| EP-0709374-B1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | OREAL (FR) | 1997-06-18 | — | — | EP | claimed |
| US-5578735-A | CATALYTIC HYDROGENATION OF INDOLE COMPOUNDS AND REFLUXING | L'OREAL (FR) | 1996-11-26 | — | — | US | claimed |
| US-5556989-A | HAIR DYES | L'OREAL (FR) | 1996-09-17 | — | — | US | claimed |
| EP-0709374-A1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | L'OREAL (FR) | 1996-05-01 | — | — | EP | claimed |
| EP-0604278-A1 | Indoline derivatives and dye compositions for keratinic fibres | L'OREAL (FR) | 1994-06-29 | — | — | EP | claimed |
| JP-6263730-A | — | — | None | — | — | JP | disclosed |
| JP-8225524-A | — | — | None | — | — | JP | disclosed |
| CN-118005554-A | Synthesis method of 5, 6-dihydroxyindole and intermediate thereof | 北京颖诺凯胜科技有限公司 | 2024-05-10 | — | — | CN | disclosed |
| EP-0604278-B1 | Indoline derivatives and dye compositions for keratinic fibres | OREAL (FR) | 2001-02-21 | — | — | EP | disclosed |
| EP-0709374-B1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | OREAL (FR) | 1997-06-18 | — | — | EP | disclosed |
| US-5578735-A | CATALYTIC HYDROGENATION OF INDOLE COMPOUNDS AND REFLUXING | L'OREAL (FR) | 1996-11-26 | — | — | US | disclosed |
| US-5556989-A | HAIR DYES | L'OREAL (FR) | 1996-09-17 | — | — | US | disclosed |
| JP-H08225524-A | PREPARATION OF INDOLE COMPOUND FROM N-PROTECTED INDOLINE | L'OREAL SA | 1996-09-03 | — | — | JP | disclosed |
| EP-0709374-A1 | Process for the preparation of indol derivatives starting from N-protected indolin compounds | L'OREAL (FR) | 1996-05-01 | — | — | EP | disclosed |
| US-5427588-A | Oxidation hair dyes; 1-oxy- or aminocarbonyl or oxy- or aminothiocarbonylindololines | L'OREAL (FR) | 1995-06-27 | — | — | US | disclosed |
| JP-H06263730-A | NOVEL INDOLINE COMPOUND, DYEING COMPOSITION COMPRISING THIS COMPOUND AS BASE AND DYEING PROCESS OF KERATINOUS FIBER | L'OREAL SA | 1994-09-20 | — | — | JP | disclosed |
| EP-0604278-A1 | Indoline derivatives and dye compositions for keratinic fibres | L'OREAL (FR) | 1994-06-29 | — | — | EP | disclosed |