Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8760465 | 0.87 | NPC1 (0.76) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL5215945 | 0.85 | NPC1 (0.69) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL30659283 | 0.84 | NPC1 (1.00) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL7469639 | 0.84 | NPC1 (1.00) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL7754907 | 0.82 | NPC1 (0.71) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL30987968 | 0.82 | NPC1 (0.71) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL5212024 | 0.81 | L3MBTL1 (0.66) | NPC1RAB9AL3MBTL1NOTUMTMEM97 | |
| SCHEMBL13234279 | 0.81 | NPC1 (0.47) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL1946342 | 0.81 | TMEM97 (0.57) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL21965354 | 0.80 | RAB9A (0.65) | NPC1RAB9AL3MBTL1NOTUMTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240154-B1 | SERINE PROTEASE INHIBITORS | TULARIK LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| US-7157585-B2 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2007-01-02 | — | — | US | disclosed |
| US-20050215587-A1 | Serine protease inhibitors | LIVELY SARAH E | 2005-09-29 | — | — | US | disclosed |
| US-6916957-B2 | Serine protease inhibitors | TULARIK LIMITED (GB) | 2005-07-12 | — | — | US | disclosed |
| US-20030018059-A1 | Serine protease inhibitors | PROTHERICS MOLECULAR DESIGN LIMITED (GB) | 2003-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215587-A1 | Serine protease inhibitors | PRSS1, TPSAB1, CMA1 | NPC1 3113/4885RAB9A 2685/4885L3MBTL1 625/4885 |
| US-20030018059-A1 | Serine protease inhibitors | TPSAB1, PRSS1, SERPINB1 | NPC1 1831/4885RAB9A 2314/4885L3MBTL1 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.