Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | CDK4 | P11802 | 4/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CDK7 | P50613 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCND1 | P24385 | 2/20 | 0.48 |
| ▸ | CCNH | P51946 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465974 | 0.81 | GAA (0.47) | CDK2IGF1RAURKBAURKAADORA2B | |
| SCHEMBL19833693 | 0.71 | ALDH1A1 (0.53) | ADORA1GAAMEN1KMT2A | |
| SCHEMBL27608176 | 0.70 | ADORA2B (0.50) | IGF1RAURKBADORA2BADORA1MAP4K4 | |
| SCHEMBL7147816 | 0.68 | ADORA2A (0.52) | ADORA2BADORA1ADORA3MEN1KMT2A | |
| SCHEMBL14234053 | 0.66 | SCN9A (0.55) | CDK2CDK4CCNE1CDK1CDK7 | |
| SCHEMBL654899 | 0.65 | AURKA (0.69) | CDK2CDK1IGF1RAURKBAURKA | |
| SCHEMBL1531622 | 0.65 | CDK2 (1.00) | CDK2CDK4CCNE1CDK1CDK7 | |
| SCHEMBL5238479 | 0.65 | ADORA2B (0.81) | AURKBADORA2BADORA1MAP4K4ADORA3 | |
| SCHEMBL10996114 | 0.64 | SCN9A (0.51) | CDK2CDK4CCNE1CDK1CDK7 | |
| SCHEMBL10974957 | 0.64 | JAK2 (0.53) | CDK2CDK1AURKAADORA2BGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | claimed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | claimed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | claimed |