Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28346436 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTMAPK10KDM4EMAPT | |
| SCHEMBL7460449 | 0.75 | PDE4D (0.52) | SMN1; SMN2HTTMAPK10SLC34A1KDM4E | |
| SCHEMBL20471481 | 0.73 | KDM4E (0.74) | SMN1; SMN2MAPK10KDM4EMAPTKMT2A | |
| SCHEMBL7456165 | 0.73 | KDM4E (0.44) | SMN1; SMN2HTTMAPK10SLC34A1KDM4E | |
| SCHEMBL8345836 | 0.73 | MAPT (0.58) | KDM4EMAPTKMT2AP2RY12FNTA | |
| SCHEMBL14705880 | 0.72 | ELANE (0.46) | SMN1; SMN2HTTMAPK10SLC34A1KDM4E | |
| SCHEMBL28724765 | 0.72 | KIF11 (0.46) | — | |
| SCHEMBL7455310 | 0.71 | FNTA (0.44) | SMN1; SMN2HTTMAPK10SLC34A1KDM4E | |
| SCHEMBL10313817 | 0.71 | SLC34A1 (0.42) | SLC34A1KDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL5093044 | 0.71 | P2RY12 (0.40) | SMN1; SMN2HTTSLC34A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |