Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5382485 | 0.83 | TDP1 (0.43) | NPY5RMEN1POLBKMT2ATDP1 | |
| SCHEMBL3918722 | 0.80 | ALDH1A1 (0.45) | NPY5RMEN1POLBKMT2AALDH1A1 | |
| SCHEMBL5387500 | 0.79 | NPY5R (0.42) | NPY5RMEN1POLBKMT2ATDP1 | |
| SCHEMBL5387497 | 0.79 | NPY5R (0.42) | NPY5RMEN1POLBKMT2ATDP1 | |
| SCHEMBL5131843 | 0.76 | ALDH1A1 (0.38) | NPY5RMEN1POLBKMT2ATDP1 | |
| SCHEMBL5382919 | 0.76 | ALDH1A1 (0.38) | NPY5RMEN1POLBKMT2ATDP1 | |
| SCHEMBL27605000 | 0.73 | — | — | |
| SCHEMBL12313412 | 0.69 | NPY5R (0.41) | NPY5RMEN1POLBKMT2AALDH1A1 | |
| SCHEMBL7470106 | 0.67 | DPP4 (0.30) | — | |
| SCHEMBL4274519 | 0.66 | FAAH (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194421-A4 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1194421-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6222040-B1 | FOR THERAPY OF EATING DISORDERS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-04-24 | — | — | US | disclosed |
| WO-2001002379-A1 | SELECTIVE NPY (Y5) ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |