Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7531464 | 0.87 | GRIK1 (0.56) | GRIK1 | |
| SCHEMBL5166524 | 0.80 | FBP1 (0.49) | GRIK1 | |
| SCHEMBL3788016 | 0.79 | FLT1 (0.52) | ALDH1A1ABL1 | |
| SCHEMBL7461264 | 0.78 | FLT1 (0.59) | ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3782284 | 0.78 | FLT1 (0.48) | GRIK1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7461533 | 0.78 | GRIK1 (0.51) | GRIK1ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL7459211 | 0.77 | FLT1 (0.45) | ALDH1A1MAPTTP53 | |
| SCHEMBL7469556 | 0.76 | TP53 (0.46) | GRIK1ALDH1A1HPGDMAPTTP53 | |
| SCHEMBL7459021 | 0.75 | FLT1 (0.50) | ALDH1A1HPGDMAPTGAA | |
| SCHEMBL3783035 | 0.73 | FLT1 (0.43) | GRIK1ALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |