Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 9/20 | 0.45 |
| ▸ | FLT4 | P35916 | 9/20 | 0.45 |
| ▸ | KDR | P35968 | 9/20 | 0.45 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802745 | 0.90 | GRIK1 (0.47) | FLT1FLT4KDRPYGL | |
| SCHEMBL3788016 | 0.81 | FLT1 (0.52) | FLT1FLT4KDRPYGLSMN1; SMN2 | |
| SCHEMBL7468666 | 0.81 | PYGL (0.44) | FLT1FLT4KDRPYGLTP53 | |
| SCHEMBL7461264 | 0.80 | FLT1 (0.59) | FLT1FLT4KDRALDH1A1LMNA | |
| SCHEMBL7459021 | 0.78 | FLT1 (0.50) | FLT1FLT4KDRMAPTSMN1; SMN2 | |
| SCHEMBL7470188 | 0.77 | GRIK1 (0.45) | TP53MAPTALDH1A1 | |
| SCHEMBL3782284 | 0.76 | FLT1 (0.48) | FLT1FLT4KDRTP53HRH3 | |
| SCHEMBL7461533 | 0.76 | GRIK1 (0.51) | FLT1FLT4KDRTP53MAPT | |
| SCHEMBL5166524 | 0.75 | FBP1 (0.49) | FLT1FLT4KDR | |
| SCHEMBL7469556 | 0.74 | TP53 (0.46) | FLT1FLT4KDRTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |