Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CCR9 | P51686 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7559587 | 0.88 | GRIK1 (0.66) | GRIK1NLRP3 | |
| SCHEMBL5166524 | 0.83 | FBP1 (0.49) | GRIK1NLRP3FLT1FLT4KDR | |
| SCHEMBL3788016 | 0.80 | FLT1 (0.52) | ALDH1A1TSHRFLT1FLT4KDR | |
| SCHEMBL7461264 | 0.79 | FLT1 (0.59) | KDM4EHSD17B10MAPK1ALDH1A1KMT2A | |
| SCHEMBL3782284 | 0.79 | FLT1 (0.48) | GRIK1ALDH1A1KMT2AHPGDFLT1 | |
| SCHEMBL7470188 | 0.78 | GRIK1 (0.45) | GRIK1ALDH1A1KMT2AHPGDMAPT | |
| SCHEMBL7469556 | 0.77 | TP53 (0.46) | GRIK1ALDH1A1HPGDFLT1FLT4 | |
| SCHEMBL7459021 | 0.77 | FLT1 (0.50) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL7459211 | 0.76 | FLT1 (0.45) | ALDH1A1TSHRFLT1FLT4KDR | |
| SCHEMBL9211442 | 0.75 | KMT2A (0.53) | GRIK1KDM4EHSD17B10MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |