Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | PGR | P06401 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427093 | 0.91 | POLB (0.50) | POLBLMNAALDH1A1CYP1A2HTT | |
| SCHEMBL11761193 | 0.82 | ALDH1A1 (0.66) | POLBLMNAALDH1A1CYP1A2HTT | |
| SCHEMBL9575469 | 0.80 | AKR1C3 (0.47) | POLBALDH1A1HPGDKMT2ARAB9A | |
| SCHEMBL29587928 | 0.76 | LMNA (0.66) | POLBLMNAALDH1A1CYP1A2HTT | |
| SCHEMBL3605144 | 0.75 | NCEH1 (0.39) | POLBLMNAALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL348831 | 0.74 | NPC1 (0.45) | POLBLMNAALDH1A1CYP1A2HTT | |
| SCHEMBL2945284 | 0.74 | CYP1A2 (0.71) | POLBLMNAALDH1A1CYP1A2HTT | |
| SCHEMBL3480945 | 0.74 | ALDH1A1 (0.71) | POLBLMNAALDH1A1CYP1A2HTT | |
| Oxybenzone SCHEMBL15551 | 0.74 | HPGD (1.00) | POLBLMNAALDH1A1CYP1A2HTT | |
| SCHEMBL3224251 | 0.74 | NPC1 (0.81) | POLBLMNAALDH1A1CYP1A2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775126-B1 | HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES | WELLCOME FOUND (GB) | 2002-10-30 | — | — | EP | disclosed |
| EP-0683774-B1 | HYPOLIPIDAEMIC COMPOUNDS | WELLCOME FOUND (GB) | 2002-10-09 | — | — | EP | disclosed |
| EP-1203769-A1 | Hypolipidemic 1,4-benzothiazepine derivative | THE WELLCOME FOUNDATION LIMITED (GB) | 2002-05-08 | — | — | EP | disclosed |
| US-5910494-A | NOVEL COMPOUNDS THAT REDUCE THE ABSORPTION OF BILE ACIDS FROM THE INTESTINE; FOR PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC CONDITIONS, SUCH AS ATHEROSCLEROSIS | GLAXO WELLCOME INC. (US) | 1999-06-08 | — | — | US | disclosed |
| WO-1998038182-A9 | HYPOLIPIDEMIC BICYCLIC DERIVATIVES | GLAXO GROUP LTD (GB) | 1999-04-15 | — | — | WO | disclosed |
| US-5817652-A | ATHEROSCLEROSIS | GLAXO WELLCOME INC. (US) | 1998-10-06 | — | — | US | disclosed |
| WO-1998038182-A1 | HYPOLIPIDEMIC BICYCLIC DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-09-03 | — | — | WO | disclosed |
| US-5723458-A | 1,4-BENZOTHIAZEPINES | GLAXO WELLCOME INC. (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0683773-B1 | HYPOLIPIDAEMIC CONDENSED 1,4-THIAZEPINES | WELLCOME FOUND (GB) | 1997-09-17 | — | — | EP | disclosed |
| WO-1994018184-A1 | HYPOLIPIDAEMIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-08-18 | — | — | WO | disclosed |
| WO-1994018183-A1 | HYPOLIPIDAEMIC CONDENSED 1,4-THIAZEPINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-08-18 | — | — | WO | disclosed |