Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470410 | 0.91 | HTR1A (0.53) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7469040 | 0.91 | DRD4 (0.50) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7471417 | 0.90 | HTR1A (0.56) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7476863 | 0.90 | KCNH2 (0.51) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7478663 | 0.87 | HTR1A (0.36) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7465127 | 0.85 | HTR1A (0.36) | HTR1ADRD2HTR2ADRD4DRD3 | |
| SCHEMBL7478658 | 0.84 | HRH4 (0.40) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7470711 | 0.83 | KCNH2 (0.51) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7464933 | 0.82 | HTR1A (0.62) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL7471385 | 0.82 | DRD2 (0.44) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755930-B1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6337397-B1 | A BENZOXAZEPINE DERIVATIVE FOR TREATMENT OF ANXIETY NEUROSIS, PHOBIAS, OBSESSIVE-COMPULSIVE DISORDERS, SCHIZOPHRENIA, POST-CARDIAC TRAUMA STRESS DISORDERS, DEPRESSION DISORDERS, PSYCHOSOMATIC DISORDERS AND OTHER PSYCHONEUROTIC DISORDERS, | SUNTORY LIMITED (JP) | 2002-01-08 | — | — | US | disclosed |
| US-6187769-B1 | Benzoxazepine derivatives and their salts and medicaments containing the same | SUNTORY LIMITED (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0755930-A1 | BENZOXAZEPINE DERIVATIVES, SALTS THEREOF, AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |