SCHEMBL7470323

SCHEMBL7470323

CCOC(=O)C(CCCCc1ccc(C)cc1)(C(=O)OCC)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.41
KCNH2 Q12809 1/20 0.41
CHRM2 P08172 1/20 0.41
CHRM3 P20309 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
PIN1 Q13526 1/20 0.40
PLAAT3 P53816 1/20 0.40
PLAAT5 Q96KN8 1/20 0.40
PLAAT2 Q9NWW9 1/20 0.40
PLAAT4 Q9UL19 1/20 0.40
EDNRB P24530 1/20 0.40
EDNRA P25101 1/20 0.40
PPARG P37231 1/20 0.39
PPARA Q07869 1/20 0.39
ALDH1A1 P00352 2/20 0.39
RECQL P46063 1/20 0.39
MMP8 P22894 1/20 0.39
ALOX5 P09917 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27941514 0.82 PIN1 (0.47) TDP1L3MBTL1PIN1ALDH1A1RECQL
SCHEMBL7470332 0.80 EDNRB (0.38) HRH1KCNH2CHRM2CHRM3TDP1
SCHEMBL11140576 0.80 SMN1; SMN2 (0.49) PIN1ALDH1A1ALOX5CYP1A2CYP3A4
SCHEMBL22119058 0.79 PIN1 (0.45) CHRM2CHRM3PIN1ALDH1A1RECQL
SCHEMBL3726225 0.78 PIN1 (0.50) CHRM2CHRM3PIN1ALDH1A1RECQL
SCHEMBL7374269 0.78 PIN1 (0.50) CHRM2CHRM3PIN1ALDH1A1RECQL
SCHEMBL5474434 0.78 PIN1 (0.53) CHRM2CHRM3PIN1ALDH1A1RECQL
SCHEMBL11274953 0.78 PIN1 (0.44) L3MBTL1PIN1PPARGPPARAALDH1A1
SCHEMBL11279345 0.77 PTPRC (0.45) TDP1L3MBTL1PIN1PLAAT3PLAAT5
SCHEMBL14783256 0.77 L3MBTL1 (0.45) CHRM2CHRM3TDP1L3MBTL1PIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6472396-B1 Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds ROCHE DIAGNOSTICS GMBH (DE) 2002-10-29 US disclosed
EP-0869947-B1 BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS ROCHE DIAGNOSTICS GMBH (DE) 2002-10-23 EP disclosed
US-6110924-A MATRIX METALLOPROTEASE INHIBITORS ROCHE DIAGNOSTICS GMBH (DE) 2000-08-29 US disclosed
EP-0869947-A1 NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1998-10-14 EP disclosed
WO-1997023465-A1 NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS BOEHRINGER MANNHEIM GMBH (DE) 1997-07-03 WO disclosed