Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.49 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465874 | 0.94 | AKR1B1 (0.50) | AKR1B1AKR1A1PPARGPPARAPPARD | |
| SCHEMBL7471563 | 0.90 | PPARG (0.48) | AKR1B1AKR1A1PPARGPPARDPSEN1 | |
| SCHEMBL7472775 | 0.88 | AKR1B1 (0.44) | AKR1B1AKR1A1PPARGPPARAPPARD | |
| SCHEMBL7472814 | 0.87 | PPARG (0.51) | AKR1B1AKR1A1PPARGPPARAPPARD | |
| SCHEMBL7465240 | 0.87 | CMA1 (0.44) | AKR1B1AKR1A1PPARGPPARAPPARD | |
| SCHEMBL7469653 | 0.85 | HDAC6 (0.43) | AKR1B1AKR1A1PPARGPPARAPPARD | |
| SCHEMBL7470720 | 0.85 | PSEN1 (0.43) | AKR1B1AKR1A1PPARGPPARAPPARD | |
| SCHEMBL7472654 | 0.85 | AKR1B1 (0.45) | AKR1B1AKR1A1AKR1B10HDAC6PTGDR2 | |
| SCHEMBL7563746 | 0.84 | MAPT (0.49) | HDAC6 | |
| SCHEMBL7461006 | 0.83 | AKR1B1 (0.42) | AKR1B1AKR1A1AKR1B10PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |