Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467040 | 0.85 | CMA1 (0.43) | HDAC6MAPTHTR6HDAC1HDAC8 | |
| SCHEMBL7470400 | 0.85 | AKR1B1 (0.49) | HDAC6PPARGPPARDPPARAHDAC1 | |
| SCHEMBL7563746 | 0.83 | MAPT (0.49) | HDAC6MAPTKMT2AS1PR2ALDH1A1 | |
| SCHEMBL7465395 | 0.82 | TP53 (0.51) | HDAC6MAPTALDH1A1HPGDTHRB | |
| SCHEMBL7463225 | 0.80 | CMA1 (0.42) | HDAC6MAPTS1PR2HDAC1HDAC8 | |
| SCHEMBL7465874 | 0.80 | AKR1B1 (0.50) | HDAC6PPARGPPARDPPARAAKR1A1 | |
| SCHEMBL7457276 | 0.80 | MAPT (0.47) | MAPTKMT2AALDH1A1HPGDTHRB | |
| SCHEMBL7465240 | 0.80 | CMA1 (0.44) | HDAC6PPARGPPARDPPARAKMT2A | |
| SCHEMBL7472833 | 0.80 | MAPT (0.48) | MAPTKMT2AALDH1A1THRBSMN1; SMN2 | |
| SCHEMBL7459066 | 0.79 | KMT2A (0.54) | MAPTKMT2AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |