Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | MAT2A | P31153 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470400 | 0.88 | AKR1B1 (0.49) | AKR1B1AKR1A1PTGDR2PPARGPPARD | |
| SCHEMBL7468729 | 0.87 | MAPT (0.46) | SMN1; SMN2 | |
| SCHEMBL7461621 | 0.86 | KDM4E (0.38) | MCL1GABRA5GABRA1MAT2APPARG | |
| SCHEMBL7465874 | 0.85 | AKR1B1 (0.50) | AKR1B1AKR1A1KMOPTGDR2PPARG | |
| SCHEMBL7457276 | 0.84 | MAPT (0.47) | SMN1; SMN2NPSR1 | |
| SCHEMBL7471563 | 0.81 | PPARG (0.48) | AKR1B1AKR1A1MCL1PTGDR2PPARG | |
| SCHEMBL7468043 | 0.81 | MAPT (0.48) | SMN1; SMN2 | |
| SCHEMBL7465813 | 0.80 | ALDH1A1 (0.43) | SMN1; SMN2NPSR1 | |
| Iodide SCHEMBL7466550 | 0.80 | MAPT (0.38) | MAT2ASMN1; SMN2 | |
| SCHEMBL8705100 | 0.79 | HTT (0.38) | MCL1MAT2AHTTSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795548-B1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LTD (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-5814631-A | CHYMASE INHIBITOR, CARDIVASCULAR | SUNTORY LIMITED (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0795548-A1 | QUINAZOLINE DERIVATIVES AND USE THEREOF | SUNTORY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |