Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.67 |
| ▸ | SYK | P43405 | 3/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CTSC | P53634 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475753 | 0.86 | IKBKB (0.67) | IKBKBCDK2NPC1MAPTMAPK1 | |
| SCHEMBL7469906 | 0.83 | IKBKB (0.63) | IKBKBSYKPIK3CAPIK3CGPIK3CB | |
| SCHEMBL7474268 | 0.83 | PIK3CA (0.65) | IKBKBSYKPIK3CAPIK3CGPIK3CB | |
| SCHEMBL7467852 | 0.82 | PIK3CA (0.65) | SYKPIK3CAPIK3CGPIK3CBCDK2 | |
| SCHEMBL7470733 | 0.76 | PIK3CA (0.66) | IKBKBSYKPIK3CAPIK3CGPIK3CB | |
| SCHEMBL7466208 | 0.76 | PIK3CG (0.72) | IKBKBSYKPIK3CAPIK3CGPIK3CB | |
| SCHEMBL7461475 | 0.76 | ABL1 (0.76) | SYKPIK3CAPIK3CGPIK3CBMEN1 | |
| SCHEMBL13924478 | 0.76 | SYK (1.00) | SYKCDK2MEN1NPC1LMNA | |
| SCHEMBL9956911 | 0.76 | PIK3CA (0.57) | IKBKBSYKPIK3CAPIK3CGPIK3CB | |
| SCHEMBL6980400 | 0.76 | CDK2 (0.69) | IKBKBPIK3CAPIK3CGPIK3CBCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |