Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.66 |
| ▸ | ABL1 | P00519 | 3/20 | 0.66 |
| ▸ | BCR | P11274 | 3/20 | 0.66 |
| ▸ | SRC | P12931 | 4/20 | 0.65 |
| ▸ | CDK2 | P24941 | 3/20 | 0.65 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.65 |
| ▸ | SYK | P43405 | 3/20 | 0.65 |
| ▸ | CDK1 | P06493 | 2/20 | 0.57 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 4/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464559 | 0.84 | IKBKB (0.53) | PIK3CAPIK3CGABL1BCRSRC | |
| SCHEMBL7466208 | 0.84 | PIK3CG (0.72) | PIK3CAPIK3CGABL1BCRSRC | |
| SCHEMBL7467324 | 0.84 | ABL1 (0.76) | PIK3CAPIK3CGABL1BCRSRC | |
| SCHEMBL7475753 | 0.84 | IKBKB (0.67) | ABL1BCRSRCCDK2CDK1 | |
| SCHEMBL2322043 | 0.83 | PIK3CG (0.70) | PIK3CAPIK3CGABL1BCRSRC | |
| SCHEMBL2331086 | 0.83 | PIK3CG (0.70) | PIK3CAPIK3CGABL1BCRSRC | |
| Hydrochloric Acid SCHEMBL16496538 | 0.82 | PIK3CG (0.69) | PIK3CAPIK3CGABL1BCRSRC | |
| SCHEMBL27115444 | 0.82 | PIK3CA (0.69) | PIK3CAPIK3CGABL1BCRSRC | |
| SCHEMBL7813342 | 0.81 | PIK3CA (0.67) | PIK3CAPIK3CGABL1BCRSRC | |
| SCHEMBL27115445 | 0.80 | PIK3CG (0.66) | PIK3CAPIK3CGABL1BCRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |