Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489145 | 0.80 | MEN1 (0.44) | HTTMEN1KMT2ATSHR | |
| SCHEMBL9285297 | 0.78 | HTT (0.53) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7466748 | 0.77 | KDM4E (0.49) | HTTALDH1A1MAPTHPGD | |
| SCHEMBL7488181 | 0.76 | HTT (0.47) | HTTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL7470931 | 0.76 | MAOA (0.49) | — | |
| SCHEMBL7137422 | 0.75 | MCL1 (0.42) | HTTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL7468641 | 0.73 | MCL1 (0.40) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7466880 | 0.73 | POLB (0.43) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7462856 | 0.72 | AR (0.47) | HTTALDH1A1HPGD | |
| SCHEMBL7465999 | 0.72 | NR4A2 (0.42) | HTTMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021181-A4 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | EP | claimed |
| EP-1021181-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-26 | — | — | EP | claimed |
| WO-1997035572-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-02 | — | — | WO | claimed |
| EP-1021181-A4 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1021181-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997035572-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |