Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137422 | 0.82 | MCL1 (0.42) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL7489145 | 0.82 | MEN1 (0.44) | HTTTSHRMEN1KMT2ACNR1 | |
| SCHEMBL9285297 | 0.77 | HTT (0.53) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7466748 | 0.77 | KDM4E (0.49) | HTTALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL7470727 | 0.76 | HTT (0.42) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL7470931 | 0.75 | MAOA (0.49) | — | |
| SCHEMBL7467140 | 0.75 | MRGPRX4 (0.49) | — | |
| SCHEMBL7466286 | 0.74 | MAOA (0.49) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7465999 | 0.73 | NR4A2 (0.42) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7467322 | 0.73 | EDNRB (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242075-A4 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1242075-A2 | INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001030752-A2 | INDOLE COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-03 | — | — | WO | disclosed |