Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462845 | 0.86 | ALOX5 (0.49) | MEN1TSHRKMT2AKDM4ECYP1A2 | |
| SCHEMBL7137422 | 0.83 | MCL1 (0.42) | MEN1TSHRKMT2AHTTKDM4E | |
| SCHEMBL7466748 | 0.83 | KDM4E (0.49) | HTTKDM4ECYP1A2CYP2C9NPSR1 | |
| SCHEMBL7488181 | 0.82 | HTT (0.47) | MEN1TSHRKMT2AHTTCNR1 | |
| SCHEMBL7465999 | 0.82 | NR4A2 (0.42) | MEN1KMT2AHTTCNR1KDM4E | |
| SCHEMBL9285297 | 0.81 | HTT (0.53) | MEN1KMT2AHTTKDM4E | |
| SCHEMBL7465568 | 0.81 | EDNRB (0.47) | MEN1TSHRKMT2AHTTKDM4E | |
| SCHEMBL7470727 | 0.80 | HTT (0.42) | MEN1TSHRKMT2AHTT | |
| SCHEMBL7470931 | 0.80 | MAOA (0.49) | — | |
| SCHEMBL7467140 | 0.80 | MRGPRX4 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242075-A4 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1242075-A2 | INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001030752-A2 | INDOLE COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-03 | — | — | WO | disclosed |