Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462661 | 0.86 | POLB (0.57) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2695402 | 0.79 | ESR1 (0.55) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1821413 | 0.74 | ALOX5 (0.43) | POLBCYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL8586520 | 0.74 | ALOX5 (0.43) | POLBCYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL16178528 | 0.74 | ESR1 (0.46) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30660130 | 0.73 | ALOX5 (0.42) | POLBCYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL12793777 | 0.72 | USP2 (0.67) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL18762444 | 0.72 | CYP3A4 (0.45) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL18762590 | 0.72 | CYP3A4 (0.45) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2575447 | 0.72 | KMT2A (0.47) | POLBCYP3A4CYP2C19NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244616-A1 | (HETERO)BICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | SmithKline Beecham plc (GB) | 2002-10-02 | — | — | EP | claimed |
| WO-2001047874-A1 | (HETERO)BICYCLYMETHANESULFONYLAMINO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-07-05 | — | — | WO | claimed |