Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.65 |
| ▸ | JAK3 | P52333 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11924746 | 0.88 | CYP1A2 (0.61) | JAK2JAK3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8255815 | 0.83 | MAPK8 (0.66) | JAK2NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7475925 | 0.82 | IKBKB (0.65) | JAK2JAK3GAAMEN1KMT2A | |
| SCHEMBL7471621 | 0.82 | MEN1 (0.59) | JAK2JAK3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7475248 | 0.81 | PLK1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4378143 | 0.80 | JAK2 (0.90) | JAK2JAK3GAAMEN1KMT2A | |
| SCHEMBL7466134 | 0.80 | MEN1 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7469184 | 0.80 | SYK (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7470447 | 0.80 | JAK2 (0.79) | JAK2JAK3GAAMEN1KMT2A | |
| SCHEMBL3518694 | 0.79 | CCNT1 (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |