Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | IKBKB | O14920 | 2/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475248 | 0.87 | PLK1 (0.58) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL3523266 | 0.86 | CCNT1 (0.54) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7469184 | 0.84 | SYK (0.54) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7466134 | 0.84 | MEN1 (0.62) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7470877 | 0.84 | CDK2 (0.70) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7475231 | 0.83 | SYK (0.66) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL3518836 | 0.82 | IKBKB (0.69) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL11924746 | 0.82 | CYP1A2 (0.61) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7470896 | 0.82 | JAK2 (0.65) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8255815 | 0.82 | MAPK8 (0.66) | MEN1KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |