Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471621 | 0.87 | MEN1 (0.59) | MEN1KMT2ACDK2KDM4EALDH1A1 | |
| SCHEMBL7469184 | 0.83 | SYK (0.54) | MEN1KMT2ACDK2KDM4EALDH1A1 | |
| SCHEMBL7466134 | 0.83 | MEN1 (0.62) | PLK1MEN1KMT2APIK3CAPIK3CB | |
| SCHEMBL7470896 | 0.81 | JAK2 (0.65) | PLK1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8255815 | 0.81 | MAPK8 (0.66) | MEN1KMT2APIK3CGCDK2KDM4E | |
| SCHEMBL3518836 | 0.81 | IKBKB (0.69) | MEN1KMT2ACDK2ALDH1A1NPC1 | |
| SCHEMBL11924746 | 0.81 | CYP1A2 (0.61) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7475231 | 0.80 | SYK (0.66) | MEN1KMT2APIK3CAPIK3CGCDK2 | |
| SCHEMBL13924481 | 0.79 | SYK (0.77) | PLK1PIK3CAPIK3CBPIK3CGCDK2 | |
| SCHEMBL3518694 | 0.79 | CCNT1 (0.54) | MEN1KMT2ACDK2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |