Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 10/20 | 0.67 |
| ▸ | BCR | P11274 | 8/20 | 0.67 |
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | PRKCA | P17252 | 5/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | PRKCG | P05129 | 1/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | PRKCH | P24723 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 1/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.53 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472256 | 0.94 | IKBKB (0.68) | ABL1BCRIKBKBPRKCAPRKCD | |
| SCHEMBL7471337 | 0.88 | IKBKB (0.64) | ABL1BCRIKBKBJAK2JAK3 | |
| SCHEMBL7474933 | 0.86 | ABL1 (0.68) | ABL1BCRIKBKBPRKCAPRKCD | |
| SCHEMBL7467416 | 0.85 | ABL1 (0.57) | ABL1BCRIKBKBPRKCAPRKCD | |
| SCHEMBL7463838 | 0.85 | ABL1 (0.57) | ABL1BCRIKBKBPRKCAPRKCD | |
| SCHEMBL7476936 | 0.82 | IKBKB (0.72) | ABL1BCRIKBKBJAK2JAK3 | |
| SCHEMBL7466239 | 0.81 | ACVR1 (0.72) | ABL1BCRIKBKBPRKCAPRKCD | |
| SCHEMBL7468367 | 0.79 | ABL1 (0.71) | ABL1BCRIKBKBPRKCAPRKCD | |
| SCHEMBL7467881 | 0.79 | ABL1 (0.63) | ABL1BCRIKBKBPRKCAPRKCD | |
| SCHEMBL14487911 | 0.78 | ABL1 (0.75) | ABL1BCRPRKCAEGFRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4876252-A | ADMINISTERING ANTIASTHMATIC OR ANTIALLERGEN | AMERICAN CYANAMID COMPANY (US) | 1989-10-24 | — | — | US | disclosed |
| US-4788195-A | TREATING ASTHMA, ALLERGIC DISEASES, INFLAMMATION AND DIABETES IN MAMMALS | AMERICAN CYANAMID COMPANY (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0233461-A2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID COMPANY (US) | 1987-08-26 | — | — | EP | disclosed |