Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2874560 | 0.73 | CYP11B1 (0.35) | CYP11B1CYP11B2KCNN4KCNA3TSHR | |
| SCHEMBL2874557 | 0.73 | CYP11B1 (0.35) | CYP11B1CYP11B2KCNN4KCNA3 | |
| SCHEMBL5357402 | 0.71 | P2RX7 (0.40) | P2RX7NOTUML3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL1121836 | 0.70 | NOTUM (0.35) | P2RX7NOTUML3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL6783355 | 0.70 | CYP1A2 (0.35) | CYP11B1CYP11B2KCNN4KCNA3 | |
| SCHEMBL23496573 | 0.69 | CYP11B1 (0.38) | L3MBTL1CYP11B1CYP11B2KCNN4KCNA3 | |
| SCHEMBL30786300 | 0.69 | CYP11B1 (0.35) | CYP11B1CYP11B2KCNN4KCNA3 | |
| SCHEMBL3148117 | 0.68 | P2RX7 (0.37) | P2RX7NOTUML3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL23496493 | 0.68 | RAB9A (0.33) | P2RX7CYP11B1CYP11B2KCNN4 | |
| SCHEMBL6778562 | 0.67 | CYP1A2 (0.45) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| CN-1158610-A | Quinoxaline derivatives useful in therapy | PFIZER LTD (IE) | 1997-09-03 | — | — | CN | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |