Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466490 | 0.86 | HTT (0.53) | HTTTDP1SMN1; SMN2LMNAPKM | |
| SCHEMBL7476827 | 0.81 | ALDH1A1 (0.51) | HTTTDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7471531 | 0.79 | HSD17B10 (0.53) | HTTTDP1ALDH1A1TP53KMT2A | |
| SCHEMBL10453217 | 0.79 | ALDH3A1 (0.48) | HTTTDP1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL16994101 | 0.79 | ALDH1A1 (0.60) | HTTTDP1SMN1; SMN2LMNAPKM | |
| SCHEMBL10878837 | 0.79 | HTT (0.62) | HTTTDP1SMN1; SMN2LMNAPKM | |
| SCHEMBL16982682 | 0.78 | ALDH1A1 (0.61) | HTTSMN1; SMN2LMNAPKMALDH1A1 | |
| SCHEMBL7467657 | 0.78 | ALDH1A1 (0.45) | HTTTDP1LMNAALDH1A1CYP19A1 | |
| SCHEMBL10035932 | 0.77 | ALDH3A1 (0.45) | HTTTDP1SMN1; SMN2LMNAPKM | |
| SCHEMBL27864377 | 0.77 | HTT (0.55) | HTTTDP1SMN1; SMN2LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711768-B1 | BENZIMIDAZOLE DERIVATIVE | MITSUI CHEMICALS INC (JP) | 2002-02-13 | — | — | EP | disclosed |
| US-5852011-A | Benzimidazole derivatives | MITSUI CHEMICALS, INC. (JP) | 1998-12-22 | — | — | US | disclosed |
| EP-0711768-A1 | BENZIMIDAZOLE DERIVATIVE | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-05-15 | — | — | EP | disclosed |