Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.48 |
| ▸ | GABRE | P78334 | 1/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472621 | 0.93 | MAPT (0.51) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7458907 | 0.90 | MAPT (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7461988 | 0.90 | MAOB (0.43) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7466748 | 0.90 | KDM4E (0.49) | MAPTHPGDKDM4EHSD17B10LMNA | |
| SCHEMBL7462845 | 0.85 | ALOX5 (0.49) | MAPTHPGDKDM4EHSD17B10LMNA | |
| SCHEMBL7465568 | 0.84 | EDNRB (0.47) | MAPTHPGDKDM4EHSD17B10LMNA | |
| SCHEMBL7465999 | 0.83 | NR4A2 (0.42) | MAPTHPGDKDM4EHSD17B10LMNA | |
| SCHEMBL7466286 | 0.83 | MAOA (0.49) | MAPTHPGDKDM4EHSD17B10LMNA | |
| SCHEMBL7467140 | 0.82 | MRGPRX4 (0.49) | MAOB | |
| SCHEMBL7470931 | 0.81 | MAOA (0.49) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021181-A4 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1021181-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997035572-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |